Wilms tumor, or nephroblastoma, is the most common primary renal malignancy in children. It accounts for approximately 90% of all pediatric kidney cancers. It typically arises from abnormal embryonal kidney tissue (metanephric blastema). The peak incidence occurs between 2 and 3 years of age. Most cases are sporadic and unilateral, but bilateral presentation occurs in about 5% to 7% of patients. Epidemiology and Risk Factors : 2 to 3 years old; rare after age 5. Gender : Slightly higher prevalence in females.
Extends beyond the kidney but completely resected.
: Approximately 10% of cases associate with congenital syndromic conditions. Associated Syndromes wilms tumor ppt new
Hematogenous metastases present. Most commonly involves the lungs, followed by the liver, bone, and brain.
Word count: ~1,450. Suitable for a 30-45 minute presentation, expandable to 2 hours with case discussions and references. Wilms tumor, or nephroblastoma, is the most common
At least 7 or more regional lymph nodes should be sampled for accurate staging, regardless of whether they appear macroscopically normal.
| Type | Favorable (FH) | Unfavorable (UH) | |------|----------------|------------------| | Triphasic (blastema, stroma, epithelium) | Anaplasia (focal or diffuse) | | Prognosis >90% survival | Requires intensified chemo | The peak incidence occurs between 2 and 3 years of age
Conclude your presentation on a hopeful yet cautious note regarding long-term survivorship.
Defined by the presence of marked nuclear enlargement (at least three times the diameter of adjacent cells), hyperchromasia, and multipolar mitotic figures.
Standard protocols and indications